First: is the mother returning?
Mother cats may leave to find food or wait until people move away. If the location is safe and kittens are warm and settled, monitor discreetly. Immediate intervention is appropriate when kittens are cold, injured, continuously crying, in danger, or the mother is known to be dead or unable to return.
Warmth comes before feeding
Very young kittens cannot regulate body temperature well. A cold kitten should be warmed gradually before feeding because hypothermia reduces gut motility and suckling ability. Use a wrapped heat source that warms only part of the nest so the kitten can move away.
Do not use cow’s milk as the main diet
If the kitten is truly orphaned, use a commercial kitten milk replacer prepared exactly as directed. Feed in a belly-down nursing position, not on the back. Forcing liquid into the mouth can cause aspiration.
Veterinary assessment
Age, hydration, body weight, fleas, congenital abnormalities, injuries, infection risk, and feeding needs should be assessed as soon as practical. Very young kittens may also need stimulation of the genital and anal area after feeding to urinate and defecate.